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Background
Lorigerlimab (previously known as MGD019) is an investigational, bispecific DART® molecule that targets PD-1 and CTLA-4. Lorigerlimab was designed to enhance CTLA-4 blockade on dual-expressing, tumor-infiltrating lymphocytes compared to a PD-1/CTLA-4 monoclonal antibody (mAb) combination therapy, while maintaining maximal PD-1 blockade on all PD-1-expressing cells.
Clinical Development
Please refer to our most recent corporate deck on our Events & Presentations page for the latest clinical information available on lorigerlimab.
Our Rights
MacroGenics retains global rights to lorigerlimab.
Clinical Trials
- Lorigerlimab (MGD019) Phase 1 dose escalation study (NCT03761017)
- Study of Lorigerlimab with Docetaxel or Docetaxel Alone in Participants with Metastatic Castration-resistant Prostate Cancer (LORIKEET) (NCT05848011)
- Vobramitamab Duocarmazine (MGC018) in Combination with Lorigerlimab Phase 1 Study in Advanced Solid Tumors (NCT05293496)
Presentations & Publications
Relevant Publications and Presentations can be found at https://www.macrogenicsstg.wpengine.com/publications/.
The safety and efficacy of investigational agents and/or investigational uses of approved products have not been established.