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MGD009 is a bispecific DART molecule that is designed to target both B7-H3 expressed on tumor cells as well as CD3, which is expressed on normal T cells.
MGD009 is being evaluated in a Phase 1 clinical trial in patients with B7-H3 positive tumors and in a separate study that combines MGD009 and MGA012 (anti-PD-1 mAb).
MacroGenics retains full worldwide rights to the B7-H3 franchise (including MGD009).