Home Pipeline

Overview

MacroGenics has a diverse portfolio of proprietary product candidates with several clinical trials currently underway or planned for the near future. Set forth below is the company’s development pipeline of product candidates for which we have retained commercialization or other important rights in the U.S. or more broadly.

Program (Target)
Indications
Pre-IND Phase 1 Phase 2 Phase 3 Partner Our Commercial Rights
Oncology
Margetuximab (HER2) Zai Lab, Green Cross Worldwide,
except Korea, China
Breast (HER2+) “SOPHIA”
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Gastric (+anti-PD-1)
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Flotetuzumab (CD123 x CD3) Servier North America,
Japan, Korea, India
AML/MDS
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AML (+MGA012)
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Planned
MGA012 (PD-1) Incyte*
Solid Tumors
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MGD013 (PD-1 x LAG-3) Zai Lab Worldwide, except China
Solid Tumors/Heme
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MGD019 (PD-1 x CTLA-4) Worldwide
Solid Tumors
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Enoblituzumab (B7–H3) Worldwide
Solid Tumors (+anti-PD-1)
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Neoadjuvant Prostate
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MGD009 (B7-H3 x CD3) Worldwide
Solid Tumors
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Solid Tumors (+MGA012)
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MGC018 (B7-H3) Worldwide
ADC/Solid Tumors
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MGD007 (gpA33 x CD3) Worldwide
Colorectal (+MGA012)
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INFECTIOUS DISEASES
MGD014 (HIV x CD3) NIAID/NIH Worldwide
HIV
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Oncology
Breast (HER2+) “SOPHIA”
Pre-IND Phase 1 Phase 2 Phase 3
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Gastric (+anti-PD-1)
Pre-IND Phase 1 Phase 2 Phase 3
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PartnerZai Lab, Green Cross
Our Commercial RightsWorldwide, except Korea, China
AML/MDS
Pre-IND Phase 1 Phase 2 Phase 3
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AML (+MGA012)
Pre-IND Phase 1 Phase 2 Phase 3
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Planned
PartnerServier
Our Commercial RightsNorth America, Japan, Korea, India
Solid Tumors
Pre-IND Phase 1 Phase 2 Phase 3
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PartnerIncyte*
Our Commercial Rights
Solid Tumors/Heme
Pre-IND Phase 1 Phase 2 Phase 3
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PartnerZai Lab
Our Commercial RightsWorldwide, except China
Solid Tumors
Pre-IND Phase 1 Phase 2 Phase 3
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Our Commercial RightsWorldwide
Solid Tumors (+anti-PD-1)
Pre-IND Phase 1 Phase 2 Phase 3
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Neoadjuvant Prostate
Pre-IND Phase 1 Phase 2 Phase 3
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Our Commercial RightsWorldwide
Solid Tumors
Pre-IND Phase 1 Phase 2 Phase 3
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Solid Tumors (+MGA012)
Pre-IND Phase 1 Phase 2 Phase 3
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Our Commercial RightsWorldwide
ADC/Solid Tumors
Pre-IND Phase 1 Phase 2 Phase 3
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Our Commercial RightsWorldwide
Colorectal (+MGA012)
Pre-IND Phase 1 Phase 2 Phase 3
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Partner
Our Commercial RightsWorldwide

INFECTIOUS DISEASES
HIV
Pre-IND Phase 1 Phase 2 Phase 3
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PartnerNIAID/NIH
Our Commercial RightsWorldwide

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*MacroGenics retains rights to develop its pipeline assets in combination with MGA012 and to manufacture a portion of global clinical and commercial supply needs of MGA012.

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